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KMID : 0545120080180010171
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Journal of Microbiology and Biotechnology
2008 Volume.18 No. 1 p.171 ~ p.175
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Translocation of VP1686 Upregulates RhoB and Accelerates Phagocytic Activity of Macrophage Through Actin Remodeling
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Bhattacharjee Rabindra N
Akira Shizuo
Park Kwon-Sam
Lida Tetsuya
Honda Takehi
Takeuchi Osamu
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Abstract
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Here, we report that Vibrio parahaemolyticus induces a rapid remodeling of macrophage actin and activates RhoB GTPase. Mutational analysis revealed that the effects depend on type III secretion system 1 regulated translocation of a V. parahaemolyticus effector protein, VP1686, into the macrophages. Remodeling of actin is shown to be necessary for increased bacterial uptake followed by initiation of apoptosis in macrophages. This provides evidence for functional association of the VP1686 in triggering an eat-me-and-die signal to the host.
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KEYWORD
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Vibrio parahaemolyticus, type III secretion system, actin remodeling, RhoB, phagocytosis
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